Neurochemical mechanisms of stimulation-produced analgesia: Comparison of tests involving tonic and phasic pain
نویسندگان
چکیده
منابع مشابه
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
Self-mutilation or self-injurious behaviour is a well known behavioural disorder in humans. The proposition that this behaviour in animals is a response to chronic pain of peripheral nerve injury has been met with controversy. In the present study a pharmacological model, which produces no sensory or motor loss was used to study how autotomy is related to pain. In a group of rats autotomy was i...
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The paragigantocellularis (PGi) nucleus constitutes a large portion of the ventral pontomedullary reticular formation. Neurons within the PGi have been implicated in a variety of functions including cardiovascular regulation, respiratory control, pain and analgesia. Investigators have demonstrated that electrical stimulation and microinjection of L-glutamate into the PGi produce antinocicepti...
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Pain perception is closely related to the attentional level and the vigilance of the subject [4]. The intensity of a pain stimulus and its sensation do often not coincide. A common experimental example is the so-called pain-inhibiting-pain effect: A stressful stimulus, e.g. persistent or chronic pain, often elevates the threshold for brief pain stimuli applied during the same time. Stressful st...
متن کاملDifferential effects on tonic and phasic reflex mechanisms produced by vibration of muscles in man.
There is evidence that transmission of the vibration wave set up by percussion in human subjects is responsible for reflex 'spread' or 'irradiation' (Lance and de Gail, 1965). The afferent pathway for reflex contraction of muscles involved in the irradiated response originates in the muscles concerned, and the latency of such a reflex is consistent with the propagated vibration wave being the a...
متن کاملTHE EFFECT OF LOCUS CERULEUS LESIONING ON TONIC AND PHASIC PAIN
Bulbospinal noradrenergic pathways are shown to have an important role in descending inhibition of pain sensation. Locus ceruleus (LC), as a rich noradrenergic nucleus in the brain stem which has projections into the dorsal horn of the spinal cord, was evaluated for antinociceptive activity by using tonic and phasic pain models in the rat. LC-lesioned rats demonstrated moderate increase in ...
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ژورنال
عنوان ژورنال: Physiological Psychology
سال: 1984
ISSN: 0090-5046
DOI: 10.3758/bf03327200